Verdens helseorganisasjons smertetrapp for kreftrelaterte smerter gjelder smerter som skyldes kreftsykdom og ikke andre smerter – Det er usikkert hvor god effekt langvarig behandling med opioider har på smertelindring. Samtidig vet vi at langvarig opioidbruk kan gi økt risiko for blant annet avhengighet, fallskader og nedsatt kognitiv funksjo
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